Fate Decides

Antigen aggregation decides the fate of the allergic immune response.

Previously, defined naturally occurring isoforms of allergenic proteins were classified as hypoallergens and therefore suggested as an agent for immunotherapy in the future. In this paper, we report for the first time the molecular background of hypoallergenicity by comparing the immunological behavior of hyperallergenic Betula verrucosa major Ag 1a (Bet v 1a) and hypoallergenic Bet v 1d, two i...

Who decides who decides?

what counts as wise? Second, does the public, after considerable thought, think that our society has a moral obligation to pursue lines of research which may benefit present and future generations? I say “moral obligation” because it is sometimes implied by advocates of recombinant D N A research that science would be guilty of a sin of omission if it did not continue and promote research so pr...

Interplay of Bcl-2 Proteins Decides the Life or Death Fate

Ever since the discovery that the founding member of the Bcl-2 family of proteins contributes to tumour development by inhibiting cell survival rather than encouraging proliferation [1], interest (and controversy) in these functionally diverse homologues has raged. The Bcl-2 family of proteins participate in multiple protein-protein interactions that govern whether a cell dies in response to to...

Live or let die; who decides an incompetent's fate? In re Storar and In re Eichner.

Your click decides your fate: Inferring Information Processing and Attrition Behavior from MOOC Video Clickstream Interactions

In this work, we explore video lecture interaction in Massive Open Online Courses (MOOCs), which is central to student learning experience on these educational platforms. As a research contribution, we operationalize video lecture clickstreams of students into cognitively plausible higher level behaviors, and construct a quantitative information processing index, which can aid instructors to be...